Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis

Christina Applegate has revealed she does not have multiple sclerosis, despite being diagnosed in 2021. She made the announcement on her podcast MeSsy, alongside friend and fellow actor Jamie-Lynn Sigler. “I’m back at square one — I don’t know what’s going on with me,” Applegate said through tears. She had become a prominent MS advocate and published a memoir about her experience. Applegate retired from acting following her diagnosis, wrapping up her role on Dead To Me. Despite the new finding, her MS-like symptoms persist. A 2024 Swiss-led study found a 15% MS misdiagnosis rate. “There’s a pretty damn high number,” Applegate said. Her doctors are now investigating what has caused her symptoms since 2021.